Grapefruit juice and medications6/7/2023 Pharmacokinetic drug interactions of new antidepressants: A review of the effects on the metabolism of other drugs. The effects of grapefruit juice on sertraline metabolism: An in vitro and in vivo study. Medicinal importance of grapefruit juice and its interaction with various drugs. Grapefruit - medication interactions: Forbidden fruit or avoidable consequences? /pmc/articles/PMC3589309/ The interaction can happen quickly and last for several days. Older research suggests that eating grapefruit while on sertraline can lead to too much sertraline in the blood due to grapefruit blocking the enzymes needed for metabolism. Grapefruit and sertraline, also known as Zoloft - can have a concerning combined effect if not monitored. This isn’t an exhaustive list of all potential interactions with grapefruit, so discretion in eating grapefruit or drinking grapefruit juice is something to consider until you are aware of the effects of your medication. Some common examples of antipsychotic drugs that interact with grapefruit include: Antipsychotic medicationsĪntipsychotic medications are typically prescribed to people who are experiencing hallucinations and delusions. The most common interaction is seen in the medication felodipine. These medications prevent calcium from entering the heart.Īccording to an older study, calcium channel blockers interact with the components of grapefruit juice to cause problems. Research indicates that some prescriptions that have interactions in this category end in the word “statin,” such as:Ĭalcium channel blockers are a category of medication used to help lower blood pressure. Grapefruit can interact with a variety of cholesterol medications. But some research indicates a reaction between grapefruit and buspirone. Most anti-anxiety medications are safe to take with grapefruit. Older research suggests that these antidepressants may interact with grapefruit: Several medications have poor interactions with grapefruit, not just antidepressants.
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